Two types of diabetes are usually seen in patients with cirrhosis: type 2 diabetes mellitus and hepatogenous diabetes (HD). The HD is an. Download Citation on ResearchGate | Hepatogenous diabetes: Pathophysiology, therapeutic options and prognosis | About 80% of patients with chronic liver. A literature search was conducted in different databases to study the topic of liver problems and diabetes. The aim of the study was to explore more about an.

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The prevalence and clinical characteristics of glucose metabolism disorders in patients with liver cirrhosis. Thus, the study concluded that Gallic acid has a protective effect against oxidative stress-induced damage in the diabetic state [ 49 ].

Diabetes and Liver an Association: Hepatogenous Diabetes Mechanism and Some Evidences

Diabetes mellitus, insulin treatment, diabetes duration, and risk of biliary tract cancer and hepatocellular carcinoma in a European cohort. Ma YJ L- Editor: A particularly interesting suggestion was made by Bogoch et al. While in the fasted state, hepatic glycogen was depleted in acute diabetes but remarkably augmented in chronic diabetes Ludwiget al.

Guidelines Upcoming Special Issues. Insulin resistance in muscular, hepatic and adipose tissues as well as hyperinsulinemia, seem to be pathophysiologic bases for HD.

Glucose tolerance and diabetes in chronic liver disease. Effect of physiologic hyperinsulinemia on glucose and lipid metabolism in cirrhosis. Diabetes increases the risk of acute hepatic failure. This abnormality is higher in disbetes with liver disease due to hepatitis C virus HCValcoholic and cryptogenic etiology.

Impact of metformin on the prognosis of cirrhosis induced by viral hepatitis C in diabetic patients. November 28, Citation: The authors expose arguments, which indicate that hepatogenous diabetes has not received enough attention for many years.


Diabetes mellitus is a group of metabolic diseases in which a person has high blood sugar, either because the pancreas does not produce enough insulin, or due to insulin resistance when cells do not respond to the insulin that is produced [ 1 ].

Enough data exists to justify a concrete relationship, between diabetes and the liver. Drug-induced hypoglycaemia in type 2 diabetes. Dig Liver Dis ; Hepatogenou mix results could be confusing and it could therefore be premature to say anything with confidence about this association.

Its use did not extend, probably because the concept was then misunderstood. Diabetes as a risk factor for infections in cirrhosis. February 22, P- Reviewer: Risk factors, pathophysiology, clinical implications and management.

Hepatogenous diabetes. Current views of an ancient problem.

Diabetes mellitus is associated with hepatic encephalopathy in patients with HCV cirrhosis. They studied the relationship between diabetes mellitus and primary liver cancer in a certain population. HD may result from decreased extraction of insulin by the damaged liver and the presence of portosystemic shunts that lead to hyperinsulinemia, which is potentiated by increases in glucagon, growth hormone, insulin-like growth factor, free fatty acids and cytokines[ 7 ]. HD is associated with an increased rate of complications of cirrhosis, decreased 5-year survival rate, and increased risk of hepatocellular carcinoma.

While glucose intolerance is not associated with it [ 48 ]. Non-alcoholic fatty liver diabettes and insulin resistance: Glucose intolerance in liver cirrhosis: Hepatotoxicity associated with acarbose therapy. Diabetes; Diabetes complications; Diabetes and liver; Diabetes and fatty liver; Diabetes and hepatitis; Diabetes and cirrhosis.

Contrary to this, a study by Adami et al. January 13, Article in press: Its pathophysiology relates to liver damage, pancreatic dysfunction, interactions between hepatitis C virus HCV and glucose metabolism mechanisms and genetic susceptibility.


Glucagonlike peptide-1 receptor agonists and dipeptidyl peptidase4 inhibitors in type 2 diabetes. The articles strictly about human studies and clinical trials were included. Hepatogenou Shokakibyo Gakkai Zasshi ; Liver failure, hepatocellular carcinoma and gastrointestinal hemorrhage are the major causes of death in cirrhotic patients with diabetes.

Hepatogenous diabetes: Is it time to separate it from type 2 diabetes?

Whether or not, therapeutic control of hyperglycemia reduces complications and mortality rates of patients with HD is unknown[ 3 ]. Though insulin therapy is currently advocated, requirement of insulin is variable and is difficult to predict. Thiazolidinediones and advanced liver fibrosis in nonalcoholic steatohepatitis: Related articles Cirrhosis diabetes mellitus hepatogenous diabetes nepatogenous resistance.

After reviewing over two hundred and fifty abstracts and articles, the relevant ones were chosen hwpatogenous inclusion on the final paper. The liver transplantation usually results in reversal of HD. However, the length of this article does not permit us to mention the details of each liver problem associated with diabetes. A case- control study. Horm Metab Res ; In a study by Kawaguchi et al.

Hepatogenous diabetes: An underestimated problem of liver cirrhosis Kumar R – Indian J Endocr Metab

Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. Diabetes mellitus at the time of diagnosis of cirrhosis is associated with higher incidence of spontaneous bacterial peritonitis, but not with increased mortality.

It is unclear how diabetes influences hepatocarcinogenesis.